3,5-Dihydroxybenzoic acid

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Wikipedia

3,5-Dihydroxybenzoic acid
Chemical structure of 3,5-dihydroxybenzoic acid
Chemical structure of 3,5-dihydroxybenzoic acid
Names
Preferred IUPAC name
3,5-Dihydroxybenzoic acid
Other names
α-Resorcylic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.002.482 Edit this at Wikidata
EC Number
  • 202-730-7
UNII
  • InChI=1S/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11) checkY
    Key: UYEMGAFJOZZIFP-UHFFFAOYSA-N checkY
  • C1=C(C=C(C=C1O)O)C(=O)O
Properties[1]
C7H6O4
Molar mass 154.121 g·mol−1
Melting point 235.3 °C (455.5 °F; 508.4 K)
soluble
Solubility in acetone soluble
Solubility in ethanol very soluble
Solubility in diethyl ether very soluble
Acidity (pKa) 4.04[2]
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Related compounds
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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3,5-Dihydroxybenzoic acid (α-resorcylic acid) is a dihydroxybenzoic acid. It is a colorless solid.

Preparation and occurrence

It is prepared by disulfonation of benzoic acid followed by hydrolysis of the disulfonate.[3]

It is a metabolite of alkylresorcinols, first identified in human urine and can be quantified in urine and plasma, and may be an alternative, equivalent biomarker of whole grain wheat intake.[4]

References

  1. ↑ Haynes, William M., ed. (2016). "3". CRC Handbook of Chemistry and Physics (PDF) (97th ed.). CRC Press. p. 190. ISBN 9781498754293.
  2. ↑ Haynes, William M., ed. (2016). "5". CRC Handbook of Chemistry and Physics (PDF) (97th ed.). CRC Press. p. 91. ISBN 9781498754293.
  3. ↑ Weston, Arthur W.; Suter, C. M. (1941). "3,5-Dihydroxybenzoic Acid". Org. Synth. 21: 27. doi:10.15227/orgsyn.021.0027.
  4. ↑ Ross, A.B.; Åman, P.; Kamal-Eldin, A. (2004). "Identification of cereal alkylresorcinol metabolites in human urine—potential biomarkers of wholegrain wheat and rye intake". Journal of Chromatography B. 809 (1): 125–130. doi:10.1016/j.jchromb.2004.06.015. PMID 15282102.