| Title | Publisher | First year | Last year | Genre | Notes |
| Detective Comics | DC Comics | 1937 | ongoing | detective | anthology aspect dropped in the 1960s |
| Feature Funnies | Everett M. "Busy" Arnold | 1937 | 1939 | humor | with issue #21, became Feature Comics |
| Adventure Comics | DC Comics | 1938 | 1983 | various, mostly superhero | |
| Action Comics | DC Comics | 1938 | ongoing | adventure, superhero | anthology aspect dropped in 1959 |
| Fantastic Comics | Fox Feature Syndicate | 1939 | 1941 | superhero | |
| Feature Comics | Quality Comics | 1939 | 1950 | superhero, humor | evolved from Feature Funnies |
| Four Color | Dell Comics | 1939 | 1962 | various | successive one-shot comics |
| Whiz Comics | Fawcett Comics | 1940 | 1953 | superhero | |
| Planet Comics | Fiction House | 1940 | 1953 | science fiction | |
| Big Shot Comics | Columbia Comics | 1940 | 1949 | superhero, humor | |
| Young Love | Crestwood Publications DC Comics | 1947 1960 | 1956 1977 | romance | acquired by DC Comics in 1963 |
| Young Romance | Crestwood Publications DC Comics | 1947 | 1977 | romance | acquired by DC Comics in 1963 |
| Adventures into the Unknown | ACG | 1948 | 1967 | horror | |
| Sweethearts | Fawcett Comics Charlton Comics | 1948 | 1973 | romance | acquired by Charlton Comics in 1954 |
| Western Comics | DC Comics | 1948 | 1961 | Western | |
| Wild Western | Marvel Comics | 1948 | 1957 | Western | |
| Prize Comics Western | Prize Comics | 1948 | 1956 | Western | |
| Girls' Love Stories | DC Comics | 1949 | 1973 | romance | |
| Romantic Story | Fawcett Comics Charlton Comics | 1949 | 1973 | romance | acquired by Charlton Comics in 1954 |
| Heart Throbs | Quality Comics | 1949 | 1972 | romance | acquired by DC Comics in 1957 |
| First Love Illustrated | Harvey Comics | 1949 | 1963 | romance | |
| Marvel Tales | Marvel Comics | 1949 | 1957 | horror | |
| Strange Worlds | Avon Comics | 1950 | 1955 | science fiction | |
| Strange Adventures | DC Comics | 1950 | 1973 | science fiction | |
| Girls' Romances | DC Comics | 1950 | 1971 | romance | |
| Six-Gun Heroes | Fawcett Comics Charlton Comics | 1950 | 1965 | Western | acquired by Charlton Comics in 1954 |
| Tales From the Crypt | EC Comics | 1950 | 1955 | horror | |
| The Vault of Horror | EC Comics | 1950 | 1955 | horror | |
| The Haunt of Fear | EC Comics | 1950 | 1954 | horror | |
| Weird Fantasy | EC Comics | 1950 | 1953 | science fiction | |
| Weird Science | EC Comics | 1950 | 1953 | science fiction | |
| Mystery in Space | DC Comics | 1951 | 1966 | science fiction | |
| House of Mystery | DC Comics | 1951 | 1983 | horror/suspense | |
| All-Star Western | DC Comics | 1951 | 1961 | Western | |
| Frontline Combat | EC Comics | 1951 | 1954 | war | |
| Strange Tales | Marvel Comics | 1952 | 1968 | horror, sci-fi, superhero | |
| Journey into Mystery | Marvel Comics | 1952 | 1966 | horror, sci-fi, superhero | anthology aspect dropped in 1964, becomes Thor |
| G.I. Combat | Quality Comics DC Comics | 1952 | 1987 | war | acquired by DC Comics in 1957 |
| Space Adventures | Charlton Comics | 1952 | 1979 | science fiction | |
| Our Army at War | DC Comics | 1952 | 1977 | war | Becomes Sgt. Rock |
| Star Spangled War Stories | DC Comics | 1952 | 1977 | war | Becomes The Unknown Soldier |
| Our Fighting Forces | DC Comics | 1954 | 1978 | war | |
| Fightin' Marines | Charlton Comics | 1955 | 1984 | war | |
| I Love You | Charlton Comics | 1955 | 1980 | romance | |
| Fightin' Army | Charlton Comics | 1956 | 1984 | war | |
| House of Secrets | DC Comics | 1956 | 1978 | horror/suspense | |
| Showcase | DC Comics | 1956 | 1970 | superhero | |
| Tales of the Unexpected | DC Comics | 1956 | 1968 | science fiction | relaunched as the horror anthology The Unexpected |
| Brides in Love | Charlton Comics | 1956 | 1965 | romance | |
| Outlaws of the West | Charlton Comics | 1957 | 1980 | Western | |
| Teen-Age Love | Charlton Comics | 1958 | 1973 | romance | |
| Just Married | Charlton Comics | 1958 | 1976 | romance | |
| Love Diary | Charlton Comics | 1958 | 1976 | romance | |
| Strange Worlds | Marvel Comics | 1958 | 1959 | science fiction | |
| Tales to Astonish | Marvel Comics | 1958 | 1968 | sci-fi, horror, superhero | anthology aspect dropped in 1964, becomes The Incredible Hulk |
| Tales of Suspense | Marvel Comics | 1959 | 1968 | sci-fi, horror, superhero | anthology aspect dropped in 1964, becomes Captain America |
| Amazing Adventures | Marvel Comics | 1961 | 1961 | fantasy, science fiction, superhero | |
| Amazing Adult Fantasy | Marvel Comics | 1961 | 1962 | sci-fi, fantasy | anthology aspect dropped in 1962, becomes The Amazing Spider-Man |
| Creepy | Warren Publishing | 1964 | 1983 | horror | |
| witzend | Wally Wood Wonderful Publishing Company | 1966 | 1985 | various | acquired by Bill Pearson (Wonderful Publishing Company) in 1968 |
| Ghostly Tales | Charlton Comics | 1966 | 1984 | horror | |
| Eerie | Warren Publishing | 1966 | 1983 | horror | |
| Weird | Eerie Publications | 1966 | 1981 | horror | |
| The Many Ghosts of Doctor Graves | Charlton Comics | 1967 | 1986 | horror | |
| Zap Comix | Apex Novelties | 1968 | 2005 | underground | |
| The Unexpected | DC Comics | 1968 | 1982 | horror | changes genre from science fiction to horror
(at Tales of the Unexpected); continues same numbering |
| The Witching Hour | DC Comics | 1969 | 1978 | horror | |
| Terror Tales | Eerie Publications | 1969 | 1979 | horror | |
| Astonishing Tales | Marvel Comics | 1970 | 1976 | Superhero | |
| Slow Death | Last Gasp | 1970 | 1979, 1992 | underground | |
| San Francisco Comic Book | San Francisco Comic Book Company Print Mint Last Gasp | 1970 | 1983 | underground | |
| Marvel Feature vol. 1 | Marvel Comics | 1971 | 1973 | superheroes | |
| Marvel Spotlight | Marvel Comics | 1971 | 1977 | superheroes | |
| Weird War Tales | DC Comics | 1971 | 1983 | war | |
| Ghostly Haunts | Charlton Comics | 1971 | 1978 | horror/suspense | |
| Savage Tales | Marvel Comics Dynamite Entertainment | 1971 2007 | 1986 2008 | fantasy, various | |
| Weird Western Tales | DC Comics | 1972 | 1980 | Weird Western | |
| Marvel Premiere | Marvel Comics | 1972 | 1981 | superheroes | |
| Tits & Clits Comix | Nanny Goat Productions Last Gasp | 1972 | 1987 | underground | |
| Snarf | Kitchen Sink Press | 1972 | 1990 | underground | |
| Wimmen's Comix | Last Gasp Renegade Press Rip Off Press | 1972 | 1992 | underground | |
| Superman Family | DC Comics | 1974 | 1982 | superhero | |
| Comix Book | Marvel Comics Kitchen Sink Press | 1974 | 1976 | underground | acquired by Kitchen Sink in 1976 |
| Star Reach | Star*Reach | 1974 | 1979 | various, mostly action | |
| Marvel Feature vol. 2 | Marvel Comics | 1975 | 1976 | superheroes | |
| Marvel Presents | Marvel Comics | 1975 | 1977 | superheroes | |
| Secrets of Haunted House | DC Comics | 1975 | 1982 | horror/suspense | |
| Batman Family | DC Comics | 1975 | 1978 | superhero | |
| Arcade | Print Mint | 1975 | 1976 | underground | |
| Heavy Metal | HM Communications Metal Mammoth | 1977 | 2023 | adult fantasy | |
| Time Warp | DC Comics | 1979 | 1980 | science fiction | |
| Marvel Spotlight | Marvel Comics | 1979 | 1981 | superheroes | |
| Epic Illustrated | Epic Comics | 1980 | 1986 | heroic fiction | |
| Gay Comix | Kitchen Sink Press Bob Ross | 1980 | 1998 | underground | |
| World War 3 Illustrated | World War 3 Illustrated | 1980 | ongoing | alternative/political | |
| RAW | Raw Books & Graphics | 1980 | 1991 | alternative | |
| Weirdo | Last Gasp | 1981 | 1993 | underground | |
| Eclipse Magazine | Eclipse Comics | 1981 | 1983 | various | |
| Marvel Fanfare | Marvel Comics | 1982 | 1997 | superhero | |
| Eclipse Monthly | Eclipse Comics | 1983 | 1984 | superheroes | |
| Dark Horse Presents | Dark Horse Comics | 1986 | 2017 | independent | volume 3 ended in 2017[1] |
| Wasteland | DC Comics | 1987 | 1989 | horror | |
| Marvel Comics Presents | Marvel Comics | 1988 | 1995 | superhero | |
| Taboo | Spiderbaby Grafix & Publications Kitchen Sink Press | 1988 | 1992, 1995 | horror | |
| A1 | Atomeka Press | 1989 | 1992 | various | |
| BLAB! | Kitchen Sink Press Fantagraphics | 1989 | 2007 | alternative | acquired by Fantagraphics in 1997 |
| Cheval Noir | Dark Horse Comics | 1989 | 1994 | international | |
| Drawn & Quarterly | Drawn & Quarterly | 1990 | ongoing | alternative | |
| Negative Burn | Caliber Comics | 1993 | 1997 | independent | |
| The Big Book Of | Paradox Press | 1994 | 2000 | independent | |
| Verotika | Verotik | 1994 | 1997 | erotic/horror | |
| Zero Zero | Fantagraphics | 1995 | 2000 | underground/alternative | |
| Keyhole | Millennium Publications Top Shelf Productions | 1996 | 1998 | independent/alternative | |
| Gangland | Vertigo Comics | 1999 | 2001 | crime | |
| Flinch | Vertigo Comics | 1998 | 1998 | horror | |
| Tomorrow Stories | America's Best Comics/Wildstorm | 1999 | 2002 | superheroes | |
| Little Lit | RAW Junior HarperCollins/Joanna Cotler Books | 2000 | 2003 | alternative/children's | Evolved into Toon Books |
| Kramers Ergot | Avodah Books Gingko Press Buenaventura Press | 2000 | ongoing | alternative | |
| Solo | DC Comics | 2004 | 2006 | superheroes | |
| Flight | Image Comics Ballantine Books | 2004 | 2011 | independent | acquired by Ballantine in 2006 |
| MOME | Fantagraphics | 2005 | 2011 | alternative | |
| Popgun | Image Comics | 2007 | 2010 | diverse | |
| Wednesday Comics | DC Comics | 2009 | 2009 | weekly showcase | |
| Robert E. Howard's Savage Sword | Dark Horse Comics | 2010 | 2015 | various | Based on Robert E. Howard works and characters |
| A+X | Marvel Comics | 2012 | 2014 | superhero | |
| Island | Image Comics | 2015 | 2017 | various | |
| Amazing Forest | IDW | 2016 | 2016 | various | |
| Vast Expanse | Township Comics | 2016 | ongoing | various | |