GPR52

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Wikipedia

GPR52
Identifiers
AliasesGPR52, G protein-coupled receptor 52
External IDsOMIM: 604106; MGI: 3643278; HomoloGene: 74561; GeneCards: GPR52; OMA:GPR52 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9293

620246

Ensembl

ENSG00000203737

ENSMUSG00000118401

UniProt

Q9Y2T5

P0C5J4

RefSeq (mRNA)

NM_005684

NM_001146330
NM_001368668

RefSeq (protein)

NP_005675

NP_001139802
NP_001355597

Location (UCSC)Chr 1: 174.45 – 174.45 MbChr 1: 160.4 – 160.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.[5][6]

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM][6]

Cannabidiol, CBD, and O-1918 are Inverse agonist at GPR52.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000203737 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000118401 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, et al. (February 1999). "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain". Brain Research. Molecular Brain Research. 64 (2): 193–198. doi:10.1016/S0169-328X(98)00277-0. PMID 9931487.
  6. 1 2 "Entrez Gene: GPR52 G protein-coupled receptor 52".
  7. ↑ Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, et al. (June 2021). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918". Heliyon. 7 (6): e07201. Bibcode:2021Heliy...707201S. doi:10.1016/j.heliyon.2021.e07201. PMC 8219759. PMID 34189291.