4-PrO-MET

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Wikipedia

4-PrO-MET
Clinical data
Other names4-Propionyloxy-MET; 4-Propionyloxy-N-methyl-N-ethyltryptamine; O-Propionyl-4-HO-MET; O-Propionylmetocin
Routes of
administration		Oral[1]
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • [3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-yl] propanoate
PubChem CID
Chemical and physical data
FormulaC16H22N2O2
Molar mass274.364 g·mol−1
3D model (JSmol)
  • CCC(=O)OC1=CC=CC2=C1C(=CN2)CCN(C)CC
  • InChI=1S/C16H22N2O2/c1-4-15(19)20-14-8-6-7-13-16(14)12(11-17-13)9-10-18(3)5-2/h6-8,11,17H,4-5,9-10H2,1-3H3
  • Key:ACMPLXDHJQJMIW-UHFFFAOYSA-N

4-PrO-MET, also known as 4-propionyloxy-N-methyl-N-ethyltryptamine or as O-propionyl-4-HO-MET, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT (psilacetin).[1][2] It is thought to be a prodrug of 4-HO-MET (metocin) similarly to 4-AcO-MET (metacetin).[1][2] 4-PrO-MET was encountered online as a novel designer drug in August or September 2025.[1][2] It is anecdotally claimed to produce more intense psychedelic visuals than psilocin (4-HO-DMT) but to be "less heavy" and to have good tolerability.[1] 4-PrO-MET is not an explicitly controlled substance in the United States[3] or in Canada.[4]

See also

References

  1. 1 2 3 4 5 "4-Pro-MET". AIPSIN (in Russian). Retrieved 1 January 2026.
  2. 1 2 3 "4-HO-MET PROP (4-propanoyloxy MET)". АИПСИН (in Russian). Retrieved 6 January 2026.
  3. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
  4. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.