Aminoalkylindoles (AAIs)[1][2] are a family of cannabinergic compound that act as a cannabinoid receptor agonist. They were synthesized by the pharmaceutical company Sterling-Winthrop in the early 1990s with a commercial potential as a new family of nonsteroidal anti-inflammatory agents.[3]
Aminoalkylindole is a class of synthetic cannabinoid compounds originally developed for cannabinoid receptor pharmacology studies but later emerged as drugs of abuse. They are often found in designer drugs known as synthetic cannabinoids (SCs) or "synthetic marijuana," and their use has been associated with various adverse health effects, including acute kidney injury (AKI) as shown in a 2012 study.[4]
Legality
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Aminoalkylindoles are now commonly found in synthetic cannabis designer drugs.[5]
In the United States, the DEA added the aminoalkylindoles JWH-200 to Schedule I of the Controlled Substances Act on 1 March 2011 for 12 months.[5][6]
References
- ↑ Nikan, Marjan; Nabavi, Seyed Mohammad; Manayi, Azadeh (2016). "Ligands for cannabinoid receptors, promising anticancer agents". Life Sciences. 146: 124–130. doi:10.1016/j.lfs.2015.12.053. PMID 26764235.
- ↑ Derosa, Thomas F. (2007). "Analgesics". Significant Pharmaceuticals Reported in US Patents. pp. 85–106. doi:10.1016/B978-008045344-6.50004-5. ISBN 978-0-08-045344-6.
- ↑ Thakur, Ganesh A.; Nikas, Spyros P.; Duclos, Richard I.; Makriyannis, Alexandros (2005). "Methods for the Synthesis of Cannabinergic Ligands". Marijuana and Cannabinoid Research. Methods in Molecular Medicine. Vol. 123. pp. 113–148. doi:10.1385/1-59259-999-0:113. ISBN 1-59259-999-0. PMID 16506405.
- ↑ "AKI Associated With Synthetic Cannabinoid Use". Medscape. Retrieved 2023-08-05.
- 1 2 "Synthetic Cannabinoids". American Association for Clinical Chemistry. 2013-02-01. Retrieved 2013-11-17.
- ↑ "Schedules of Controlled Substances: Temporary Placement of Five Synthetic Cannabinoids Into Schedule I". Federal Register. 2011-03-01. Retrieved 2013-11-17.